Therapeutic Efficacy of Chlorine Dioxide (ClO₂) in Periodontal Management

Drawing on over 25 years of pioneering research by Frontier Pharmaceutical and Howard Alliger—the originator of active chlorine dioxide antimicrobial technology—current evidence validates ClO₂ as a potent, non-cytotoxic agent for managing periodontal disease.

Through selective oxidative action, ClO₂ targets the sulfur-containing amino acids vital to the survival of anaerobic "Red" and "Orange" complex pathogens, effectively disrupting biofilm architecture and neutralizing inflammatory volatile sulfur compounds (VSCs) without inducing bacterial resistance.

Meet Janice Rountree, FAAOSH, IAOMT

With over 40 years of dedicated practice as a dental hygienist—including 14 years specializing in integrative dental hygiene—Janice Rountree has built a reputation as a trusted leader in evidence-based care. She is at the forefront of chlorine dioxide therapy for periodontal disease management, seamlessly blending conventional treatment with advanced antimicrobial protocols to deliver results that truly make a difference for her patients.

Fellow, American Academy for Oral Systemic Health (FAAOSH)

Advanced certification in oral-systemic health connections

International Academy of Oral Medicine & Toxicology (IAOMT)

Holistic Dental Hygiene Accreditation

Clinical Research Expertise

Published research on biofilm disruption and antimicrobial therapy

Janice Rountree presenting The Paradigm Shift

Vision & Mission

Redefining oral-systemic excellence through advanced biofilm disruption and protocol-driven wellness

Vision

To redefine the standard of oral-systemic excellence by making DioxiCare the global synonym for advanced biofilm disruption, where peak microbial health is recognized as the ultimate foundation of modern wellness and longevity.

Mission

We empower elite dental teams to deliver predictable, protocol-driven wellness through our proprietary active chlorine dioxide platform. By bridging the gap between salivary diagnostics and clinical execution, we provide the fresh-use technology necessary for sophisticated microbial management and superior patient outcomes.

Comprehensive Research Materials

Access detailed presentations, clinical evidence, and peer-reviewed citations supporting Chlorine Dioxide therapy in periodontal disease management.

Presentations

14-slide comprehensive presentation with speaker notes and timing guide

Key Findings

Clinical evidence on ClO₂ efficacy against A. actinomycetemcomitans and pathogenic complexes

Citations

54 peer-reviewed references organized by research category

About

Learn more about this research and how to use these materials

Book a Lunch n' Learn or Study Club Presentation

Invite Janice Rountree to present evidence-based research on Chlorine Dioxide biofilm disruption therapy to your dental team or study club. Interactive presentations include clinical protocols, case studies, and Q&A sessions.

Lunch n' Learn

60-minute presentation for your dental practice team

Study Club

90-minute in-depth presentation with clinical evidence

Biofilm Disruption Therapy - ClO₂ molecular action from salivary diagnostics to oral systemic health

Understanding Biofilm-Associated Infections

Periodontal disease is fundamentally a biofilm-associated infection. The extracellular polymeric substance (EPS) matrix provides bacteria with up to 1000-fold increased resistance to conventional antimicrobials.