Key Clinical Findings
Evidence-based research on ClO₂ efficacy against periodontal pathogens
Red Complex Pathogens
High-risk periodontal bacteria
- Porphyromonas gingivalis
Most virulent periodontal pathogen
- Tannerella forsythia
Key anaerobic species
- Aggregatibacter actinomycetemcomitans
Aggressive periodontitis driver
60-90% reduction
Orange Complex Pathogens
Moderate-risk bridge species
- Prevotella intermedia
Bridge species
- Fusobacterium nucleatum
Biofilm connector
Matrix disruption
ClO₂ Advantages for Aggressive Periodontitis
Multiple Virulence Factor Targeting
Non-specific mechanism targets all pathways simultaneously
Biofilm Resistance Overcome
Penetrates and disrupts EPS matrix effectively
Resistance Prevention
Non-specific oxidation prevents resistance development
Superior Compliance
No tooth staining, minimal taste change
Clinical Outcomes
Primary Outcomes
- • Reduced probing depth (6-8mm → 2-3mm)
- • Decreased bleeding on probing
- • Lower bacterial load (60-90% reduction)
- • Improved periodontal health