Therapeutic Efficacy of Chlorine Dioxide (ClO₂) in Periodontal Management
Drawing on over 25 years of pioneering research by Frontier Pharmaceutical and Howard Alliger—the originator of active chlorine dioxide antimicrobial technology—current evidence validates ClO₂ as a potent, non-cytotoxic agent for managing periodontal disease.
Through selective oxidative action, ClO₂ targets the sulfur-containing amino acids vital to the survival of anaerobic "Red" and "Orange" complex pathogens, effectively disrupting biofilm architecture and neutralizing inflammatory volatile sulfur compounds (VSCs) without inducing bacterial resistance.
Meet Janice Rountree, FAAOSH, IAOMT
With over 25 years of experience in integrative dental hygiene, Janice Rountree is a recognized leader in evidence-based chlorine dioxide therapy for periodontal disease management. Her pioneering work bridges conventional periodontal treatment with cutting-edge antimicrobial protocols.
Fellow, American Academy for Oral Systemic Health (FAAOSH)
Advanced certification in oral-systemic health connections
International Academy of Oral Medicine & Toxicology (IAOMT)
Holistic Dental Hygiene Accreditation
Clinical Research Expertise
Published research on biofilm disruption and antimicrobial therapy
Vision & Mission
Redefining oral-systemic excellence through advanced biofilm disruption and protocol-driven wellness
To redefine the standard of oral-systemic excellence by making DioxiCare the global synonym for advanced biofilm disruption, where peak microbial health is recognized as the ultimate foundation of modern wellness and longevity.
We empower elite dental teams to deliver predictable, protocol-driven wellness through our proprietary active chlorine dioxide platform. By bridging the gap between salivary diagnostics and clinical execution, we provide the fresh-use technology necessary for sophisticated microbial management and superior patient outcomes.
Comprehensive Research Materials
Access detailed presentations, clinical evidence, and peer-reviewed citations supporting Chlorine Dioxide therapy in periodontal disease management.
Book a Lunch n' Learn or Study Club Presentation
Invite Janice Rountree to present evidence-based research on Chlorine Dioxide biofilm disruption therapy to your dental team or study club. Interactive presentations include clinical protocols, case studies, and Q&A sessions.
Understanding Biofilm-Associated Infections
Periodontal disease is fundamentally a biofilm-associated infection. The extracellular polymeric substance (EPS) matrix provides bacteria with up to 1000-fold increased resistance to conventional antimicrobials.
Red Complex Pathogens
P. gingivalis, T. forsythia, T. denticola, and A. actinomycetemcomitans
Orange Complex Pathogens
P. intermedia, F. nucleatum, and P. micros
ClO₂ Mechanism
Non-specific oxidative disruption of biofilm matrix and virulence factors
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